1376P Association of dynamic change in patient-reported pain with survival in metastatic castrate sensitive prostate cancer: Exploratory analysis of LATITUDE study

Pain is an important dimension of quality-of-life in patients with metastatic castrate-sensitive prostate cancer (mCSPC). However, it unclear if dynamic change pain over time can predict for overall survival (OS) or to radiographic progression (TTRP) these patients. This exploratory analysis LATITUDE, which men de novo mCSPC were randomized receive either ADT plus abiraterone versus alone. Information was collected on patient-reported worst score (WPS) from the Brief Inventory-Short Form. We applied separate univariate joint models determine association changes WPS OS and TTRP, respectively. For time-to-event submodel, a Cox proportional hazard regression model constructed. longitudinal linear mixed effect built. The two submodels linked through random effect. fitted use Markov chain Monte Carlo algorithms. Overall, 1125 at least 3 measurements eligible. Patients initially stratified into categories based presence baseline pain. Median without any 35.7 41.1 months median TTRP 31.8 23.1 months, On multivariable regression, 1 unit higher associated inferior (hazard ratio [HR]: 1.05 [95%confidence interval [CI]: 1.02-1.09]; dependent area under curve [tAUC] 0.64) (HR: [1.01-1.08]; tAUC 0.64). independent modeling, increase current value by 1-unit 1.32 [1.26-1.38]; 0.74) 0.70). above findings highlight potential interplay between mCSPC. Compared pain, such assessment found have superior predictive ability as denoted tAUC. Dynamic evaluation has tailor subsequent treatment response initial therapy beyond its role very quality-of-life.